PrimerAntitüberküloz İlaçlara Dirençli MycobacterumTuberculosis Kompleks İzolatlarında Dirençle İlişkili Yaygın Mutasyonların Araştırılması
Methods: MTBC isolates obtained from clinical samples at the mycobacteriology laboratory of Dicle University Hospital from January 2014 to August 2019 were included. Results: TCG/TTG mutation at codon 531 of rpoB gene was the common mutation responsible for resistance in 19 (57.6%) RIF resistant iso...
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Published in | Dicle tıp dergisi Vol. 51; no. 3; pp. 461 - 469 |
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Main Authors | , , , |
Format | Journal Article |
Language | Turkish |
Published |
Diyarbakir
Dicle University
01.09.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Methods: MTBC isolates obtained from clinical samples at the mycobacteriology laboratory of Dicle University Hospital from January 2014 to August 2019 were included. Results: TCG/TTG mutation at codon 531 of rpoB gene was the common mutation responsible for resistance in 19 (57.6%) RIF resistant isolates, AGC/ACC mutation in katG315 gene region in 14 (46.7%) INH resistant isolates and C/T mutations at position -15 of inhA gene region in 8 (26.7%) INH resistant isolates. Conclusion: The genotypic test (GenoType MTBDR plus) used to identify mutations associated with resistance to primary antituberculosis drugs revealed that the most common mutations linked to rifampicin resistance were the TCG/TTG mutation located at codon 531 of the rpoB gene, the AGC/ACC (Ser315Thr) mutation located at codon 315 of the katG gene, and C/T mutations at position -15 in the inhA gene region. The AGC/ACC (Ser315Thr) mutation at codon 315 of the katG gene and C/T mutations at position -15 of the inhA gene region were identified as the most common contributors to resistance, aligning with results from earlier studies on the subject. |
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ISSN: | 1300-2945 1308-9889 |
DOI: | 10.5798/dicletip.l552636 |