1256-P: Studying Mortality in Patients with Diabetes over 75 Years

• Published in: Diabetes (New York, N.Y.) Vol. 73; p. 1
• Main Authors: Koide, Sakiho, Itou, Takaya, Kojima, Hideomi, Mukai, Tomomi, Nakasone, Yasuto, Miyakoshi, Takahiro, Yamashita, Koh, Aizawa, Toru
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2024
• Subjects: Death; Diabetes; Diabetes mellitus; Disease management; Glucose; Hyperglycemia; Hypoglycemic agents; Mortality; Renal failure
• ISSN: 0012-1797; 1939-327X
• DOI: 10.2337/db24-1256-P

Introduction & Objective: In general, less stringent glucose management is recommended for elderly patients with diabetes. Yet, little has been known regarding actual incidence of adverse events as a function of glucose for patients over 75 years (the old-old). Aim of this study was to clarify total mortality rate (MR) and the MR related to diabetes as a function of glucose in the old-old patients with diabetes. Methods: Consecutive 3172 patients with diabetes over 75 years who visited A hospital as new patients during 2012 and 2020 were retrospectively analysed. Of these, 1459 have been followed up for the mean of 4.1 years or until death whichever comes first. The average HbA1c obtained from the initial and the last sample was taken as the mean HbA1c of each patient. The use of oral hypoglycemic agents (OHA) and insulin, one year after the initial visit were registered in which SU, DPP4i, biguanide and SGLT2i were differentiated. Cox proportional hazards model was used to calculate hazard ratio (HR) for total or diabetes-related (stroke, coronary events and renal failure) death associated with Quartile (Q) of HbA1c. The rest (N=1703) dropped out during the study. Results: The drop-outs and the study subjects were not significantly different. HR was J-shaped for total death and skewed U-shaped for diabetes-related death (Fig. 1). Conclusion: Mild hyperglycemia is not associated with increased mortality in the old-old.