Visible‐Light‐Induced Domino Cyclization to Access Pyridopyrimidine‐2,4‐diones via a Radical‐Polar Crossover Reaction

Comprehensive SummaryCatalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing. We now report a radical‐polar crossover (RPC)‐enabled three‐component cyclization of bromodifluoroalkyls with enaminones and 6‐aminouraciles via a visible‐light‐induced domino c...

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Bibliographic Details
Published inChinese journal of chemistry Vol. 42; no. 19; pp. 2346 - 2350
Main Authors Zuo, Wanqing, Cheng, Yu, Zhu, Zhizhen, Zuo, Lingling, Geng, Xiao, Li, Zhifang, Wang, Lei
Format Journal Article
LanguageEnglish
Published Shanghai Wiley Subscription Services, Inc 01.10.2024
Subjects
Chemical synthesis
Crossovers
Substrates
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Summary:Comprehensive SummaryCatalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing. We now report a radical‐polar crossover (RPC)‐enabled three‐component cyclization of bromodifluoroalkyls with enaminones and 6‐aminouraciles via a visible‐light‐induced domino cyclization. The reaction exhibited a broad substrate scope (> 40 examples) including complex molecules, which highlighted the utility of this strategy for the construction of a library of bioactive analogs.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.202400315