Silver-enriched Microdomain Patterns as Advanced Bactericidal Coatings for Polymer-based Medical Devices

Today, it would be difficult for us to live a full life without polymers, especially in medicine, where its applicability is constantly expanding, giving satisfactory results without any harm effects on health. This study focused on the formation of hexagonal domains doped with AgNPs using a KrF exc...

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Bibliographic Details
Published inarXiv.org
Main Authors Pryjmakova, Jana, Vokata, Barbora, Slouf, Miroslav, Hubacek, Tomas, Martinez-Garcia, Patricia, Rebollar, Esther, Slepicka, Petr, Siegel, Jakub
Format Paper
LanguageEnglish
Published Ithaca Cornell University Library, arXiv.org 28.06.2024
Subjects
Antiinfectives and antibacterials
Biocompatibility
Biomedical materials
E coli
Excimer lasers
Excimers
Krypton fluoride lasers
Laser beams
Nanoparticles
Polyether ether ketones
Polymers
Silver
Toxicity
X ray photoelectron spectroscopy
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Summary:Today, it would be difficult for us to live a full life without polymers, especially in medicine, where its applicability is constantly expanding, giving satisfactory results without any harm effects on health. This study focused on the formation of hexagonal domains doped with AgNPs using a KrF excimer laser ({\lambda}=248 nm) on the polyetheretherketone (PEEK) surface that acts as an unfailing source of the antibacterial agent - silver. The hexagonal structure was formed with a grid placed in front of the incident laser beam. Surfaces with immobilized silver nanoparticles (AgNPs) were observed by AFM and SEM. Changes in surface chemistry were studied by XPS. To determine the concentration of released Ag+ ions, ICP-MS analysis was used. The antibacterial tests proved the antibacterial efficacy of Ag-doped PEEK composites against Escherichia coli and Staphylococcus aureus as the most common pathogens. Because AgNPs are also known for their strong toxicity, we also included cytotoxicity tests in this study. The findings presented here contribute to the advancement of materials design in the biomedical field, offering a novel starting point for combating bacterial infections through the innovative integration of AgNPs into inert synthetic polymers.
ISSN:2331-8422