Macro Mineral Levels as Markers For Senile Cataract- A Case Control Study

• Published in: NeuroQuantology Vol. 22; no. 3; p. 141
• Main Authors: Shaik Hasareen, Chaitra, M C
• Format: Journal Article
• Language: English
• Published: Bornova Izmir NeuroQuantology 01.01.2024
• Subjects: Calcium; Cataracts; Homeostasis; Lenses; Magnesium; Parameters; Permeability; Phosphorus; Statistical analysis
• ISSN: 1303-5150
• DOI: 10.48047/nq.2024.22.3.NQ24015

INTRODUCTION Cataract surgery stands as one of the most prevalent surgical interventions globally, addressing the opacification of the crystalline lens, a condition known as cataract. Responsible for over half of blindness cases. Multitude factors leading to opacity of lens. Calcium, magnesium, and phosphorus collectively play pivotal roles in lens permeability, equilibrium regulation, and homeostasis. Calcium contributes to normal permeability and dynamic equilibrium regulation between the lens and its surrounding fluid. Magnesium-dependent ATPases maintain lens homeostasis, crucial for cellular functions. Additionally, phosphorus likely influences these processes, though its specific mechanisms warrant further exploration. Understanding the interplay of these minerals is essential for unraveling the complexities of lens physiology and pathology. OBJECTIVE The primary goal of this study is to comprehend the variations in serum calcium, phosphorus, magnesium levelsand the ratio of calcium to magnesium in senile cataract patients in comparison to individuals without cataracts. MATERIALS AND METHODS This prospective study involved a total of 168 participants, comprising 84 individuals with cataracts as cases and 84 without cataracts as controls.Both groups consisted of patients aged 50 years and above.Serum levels of calcium, magnesium, and phosphorus were measured and compared between the two groups. RESULTS The data collected in this study underwent statistical analysis.An independent t-test was employed to establish associations between the parameters.Thefindings indicate significantly elevated levels of serum calcium, phosphorusand the calcium: magnesium ratio in cataract patients (p<0.05) compared to the control group. CONCLUSION Monitoring these parameters at regular intervals can prove beneficial in extending the period before obvious cataract development necessitating medical intervention.