2‐Oxabicyclohexanes: Synthesis, Properties, and Validation as Bioisosteres of ortho‐ and meta‐Benzenes

We have developed a general and practical approach towards 2‐oxabicyclo[2.1.1]hexanes with two and three exit vectors via an iodocyclization reaction. The obtained compounds have been easily converted into the corresponding building blocks for use in medicinal chemistry. 2‐Oxabicyclo[2.1.1]hexanes h...

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Published inAngewandte Chemie Vol. 136; no. 19
Main Authors Levterov, Vadym V, Panasiuk, Yaroslav, Shablykin, Oleh, Stashkevych, Oleksandr, Sahun, Kateryna, Rassokhin, Artur, Sadkova, Iryna, Lesyk, Dmytro, Anisiforova, Anna, Holota, Yuliia, Petro Borysko, Bodenchuk, Iryna, Voloshchuk, Nataliya M, Mykhailiuk, Pavel K
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.05.2024
Subjects
Agrochemicals
Hexanes
Vectors
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Summary:We have developed a general and practical approach towards 2‐oxabicyclo[2.1.1]hexanes with two and three exit vectors via an iodocyclization reaction. The obtained compounds have been easily converted into the corresponding building blocks for use in medicinal chemistry. 2‐Oxabicyclo[2.1.1]hexanes have been incorporated into the structure of five drugs and three agrochemicals, and validated biologically as bioisosteres of ortho‐ and meta‐benzenes.Dedicated to the people of Ukraine
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202319831