Changes of serum TNF-α, IL-6 and IL-18 levels in depressive disorder patients before and after treatment

• Published in: Sichuan Jingshen Weisheng Vol. 33; no. 4; p. 317
• Main Authors: Ni, Fan, Luo Yayan, Zhang, Jie, Ou Yufen, He, Hongbo
• Format: Journal Article
• Language: Chinese
• Published: Chengdu Editorial Office of Sichuan Mental Health 01.01.2020
• Subjects: Cytokines; Disease; Length of stay; Patients; Tumor necrosis factor-TNF
• ISSN: 1007-3256
• DOI: 10.11886/scjsws20200407001

ObjectiveTo investigate the changes of serum levels of tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and interleukin-18 (IL-18) in patients with depressive disorder before and after treatment, and to certify their roles in disease development. MethodsA total of 48 inpatients with depressive disorder (patient group) who met the diagnostic criteria of the international Classification of Diseases, tenth edition (ICD-10) were enrolled, and 64 healthy individuals (control group) were also recruited. Venous blood samples of both groups were collected before and after treatment. Serum TNF-α, IL-6, and IL-18 levels of all selected subjects were detected by ELISA. Clinical data such as the previous hospitalization times, length of stay, course of disease, age of onset and clinical dosage were collected. Depression status of patients was assessed using Hamilton Depression Scale-17 item (HAMD-17). ResultsBefore treatment, TNF-α and IL-6 levels in patient group were higher than those in control group [(3.40±1.46) p