Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma

• Published in: American journal of respiratory and critical care medicine Vol. 209; no. 3; p. 262
• Main Authors: Wechsler, Michael E, Scelo, Ghislaine, Larenas-Linnemann, Désirée, Torres-Duque, Carlos A, Maspero, Jorge, Tran, Trung N, Murray, Ruth B, Martin, Neil, Menzies-Gow, Andrew N, Hew, Mark, Peters, Matthew J, Gibson, Peter G, Christoff, George C, Popov, Todor A, Côté, Andréanne, Bergeron, Celine, Dorscheid, Delbert, Fitzgerald, J Mark, Chapman, Kenneth R, Boulet, Louis Philippe, Bhutani, Mohit, Sadatsafavi, Mohsen, Jiménez-Maldonado, Libardo, Duran-Silva, Mauricio, Rodriguez, Bellanid, Celis-Preciado, Carlos Andres, Cano-Rosales, Diana Jimena, Solarte, Ivan, Fernandez-Sanchez, Maria Jose, Parada-Tovar, Patricia, von Bülow, Anna, Bjerrum, Anne Sofie, Ulrik, Charlotte S, Assing, Karin Dahl, Rasmussen, Linda Makowska, Hansen, Susanne, Altraja, Alan, Bourdin, Arnaud, Taille, Camille, Charriot, Jeremy, Roche, Nicolas, Papaioannou, Andriana I, Kostikas, Konstantinos, Papadopoulos, Nikolaos G, Salvi, Sundeep, Long, Deirdre, Mitchell, Patrick D, Costello, Richard, Sirena, Concetta, Cardini, Cristina, Heffler, Enrico, Puggioni, Francesca, Canonica, Giorgio Walter, Guida, Giuseppe, Iwanaga, Takashi, Al-Ahmad, Mona, García, Ulises, Kuna, Piotr, Fonseca, João A, Al-Lehebi, Riyad, Koh, Mariko S, Rhee, Chin Kook, Cosio, Borja G, de Llano, Luis Perez, Perng, Diahn-Warng (Steve), Huang, Erick Wan-Chun, Wang, Hao-Chien, Tsai, Ming-Ju, Mahboub, Bassam, Salameh, Laila Ibraheem Jaber, Jackson, David J, Busby, John, Heaney, Liam G, Pfeffer, Paul E, Goddard, Amanda Grippen, Wang, Eileen, Hoyte, Flavia C L, Chapman, Nicholas M, Katial, Rohit, Carter, Victoria, Bulathsinhala, Lakmini, Eleangovan, Neva, Ariti, Con, Lyu, Juntao, Porsbjerg, Celeste, Price, David B
• Format: Journal Article
• Language: English
• Published: New York American Thoracic Society 01.02.2024
• Subjects: Asthma; Biological products; Clinical outcomes; Comorbidity; Eczema; Polyps; Rhinitis; Sinusitis
• ISSN: 1073-449X; 1535-4970
• DOI: 10.1164/rccm.202301-0067OC

Wechsler et al examine the association between type 2-related comorbidities and biologic agent effectiveness in adults with severe asthma (SA). They used International Severe Asthma Registry data from 21 countries (2017-2022) to quantify changes in four outcomes before and after biologic therapy in patients with or without allergic rhinitis, chronic rhinosinusitis (CRS) with or without nasal polyps (NPs), NPs, or eczema-atopic dermatitis. The findings highlight the importance of systematic comorbidity evaluation. The presence of CRS with or without NPs or NPs alone may be considered a predictor of the effectiveness of biologic agents in SA patients.