SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2- THIOXOTHIAZOLIDINE 4-ONES BASED DERIVATIVES

Antimicrobial resistance has risen in recent years, owing to the overuse and misuse of antibiotics in particular. As a result, numerous bacterial strains have been hypermutated, and resistant germs have spread.Literature review reveals that 2-thioxothiazolidin have been reported to possess potent an...

Full description

Saved in:
Bibliographic Details
Published inNeuroQuantology Vol. 20; no. 10; p. 866
Main Authors Sri, S Usha, NAMRATHA, J RISY
Format Journal Article
LanguageEnglish
Published Bornova Izmir NeuroQuantology 01.01.2022
Subjects
Antibiotics
Antimicrobial agents
Bacteria
Biological activity
Dilution
Drug development
Drug resistance
E coli
Ethanol
Fungi
Gram-positive bacteria
Literature reviews
Microorganisms
Natural products
NMR
Nuclear magnetic resonance
Pharmacy
Synthesis
Online AccessGet full text

Cover

More Information
Summary:Antimicrobial resistance has risen in recent years, owing to the overuse and misuse of antibiotics in particular. As a result, numerous bacterial strains have been hypermutated, and resistant germs have spread.Literature review reveals that 2-thioxothiazolidin have been reported to possess potent antimicrobial activities. We synthesizedthe (Z)-5- substituted benzylidene-3-(pyrrolidin-1- ylmethyl)-2-thioxothiazolidin-4-one derivatives (U1-U15) with potent antimicrobial activities. Synthesized compounds were characterized by IR, 1H?NMR, and mass spectral data. The spectral data of the synthesized compounds are in accordance with the assigned structures. Title analogs were tested for their anti-microbial activity by paper disc diffusion method and agar streak dilution method against B. subtilis, E. coli, A. niger&P. chrysogenum. All compounds exhibited weak to potent anti-microbial activity compared to standard Ciprofloxacin and Ketoconazole. The most potent compound of the series was found to be (Z)-5-(4-chlorobenzylidene)-3-(pyrrolidin-1-ylmethyl)-2- thioxothiazolidin-4-one(U3). Hence, this compound may serve as a clinically useful lead for antimicrobial drug development in the future.
ISSN:1303-5150
DOI:10.14704/nq.2022.20.10.NQ55065