Formulation Development and In-Vitro Evaluation of Telmisartan Nanocochleates

One of the biggest issues in medication formulation is enhancing the bioavailability of medicines that are poorly water soluble. The formulation of nanocochleates is one of the most acclaimed and cutting-edge medication delivery systems for this problem. There are several strategies, such as the bin...

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Bibliographic Details
Published inNeuroQuantology Vol. 20; no. 19; p. 2301
Main Authors Ghode, Prashant D, Kadlag, Sayali S, Pachauri, Asawari D, Sayare, Atul S, Pandit, Ashlesha P, Ghode, Shweta P, Salunkhe, Kishor S
Format Journal Article
LanguageEnglish
Published Bornova Izmir NeuroQuantology 01.01.2022
Subjects
Bioavailability
Calcium ions
Electron microscopes
Ethanol
Lipids
Liposomes
Particle size
Peptides
Pharmaceutical sciences
Pharmacy
Phosphatidylcholine
Quality control
Trapping
Water chemistry
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Summary:One of the biggest issues in medication formulation is enhancing the bioavailability of medicines that are poorly water soluble. The formulation of nanocochleates is one of the most acclaimed and cutting-edge medication delivery systems for this problem. There are several strategies, such as the binary aqueous-aqueous emulsion system, the hydrogel method, the direct calcium method, and the liposome method before cochleates dialysis, but trapping methods are straightforward and affordable. The current study's goal was to create nanocochleates of the poorly water-soluble medication Telmisartan (TLM). Phosphatidylcholine and cholesterol were used to create the liposome, which was subsequently transformed into nanocochleates utilizing the trapping technique. By incorporating calcium ions into premade nanoliposomes (TLMNL), TLM-loaded nanocochleates (TLMNC) were created.
ISSN:1303-5150
DOI:10.48047/nq.2022.20.19.NQ99194