ETHNOPHARMACOLOGY OF SUNGKAI LEAF (Peronema canescens Jack.) ON TERATOGENIC EFFECTS IN FEMALE WHITE MICE (Mus musculus L.)

One of the ethnopharmacology of medicinal plants has been passed down from generation to generation by the Indonesian people, namely Sungkai leaves. Sungkai (Peronema canescens Jack.) is one of the efficacious plants used in traditional medicine in Indonesia. Sungkai leaves have several bioactive co...

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Published inNeuroQuantology Vol. 20; no. 19; p. 2252
Main Authors Diliarosta, Skunda, Almahdy, A, Lestari, Hanifah Dhiya, Kurniawan, Hendra, Biomechy Oktomalio Putri, Aulia Azhar, Yohannes Alen, Dillasamola, Dwisari
Format Journal Article
LanguageEnglish
Published Bornova Izmir NeuroQuantology 01.01.2022
Subjects
Analgesics
Animals
Antiparasitic agents
Cultural heritage
Drug dosages
Ethanol
Ethnopharmacology
Ethyl acetate
Females
Fetuses
Flavonoids
Herbal medicine
Immunomodulators
Leaves
Medicine
Metabolites
Phytochemicals
Pregnancy
Toxicity
Womens health
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Summary:One of the ethnopharmacology of medicinal plants has been passed down from generation to generation by the Indonesian people, namely Sungkai leaves. Sungkai (Peronema canescens Jack.) is one of the efficacious plants used in traditional medicine in Indonesia. Sungkai leaves have several bioactive compounds that act as antimalarials, antiplasmodial, antibacterials, analgesics, and immunomodulators. This study aims to determine the teratogenic effect of administering the ethyl acetate fraction of sungkai leaves on mice during pregnancy. A total of 24 pregnant mice were divided into four groups: group 1 as a negative control (Na CMC 0.5%), groups 2, 3, and 4 were given fractions with doses of 28, 56, and 84 mg/kg BW, respectively. The fractions were given at the organogenesis phase from the 6th day to the 15th day of pregnancy.
ISSN:1303-5150
DOI:10.48047/nq.2022.20.19.NQ99190