Antitumor Effect and Molecular Mechanism of Ophiopogonin B

• Published in: Plant diseases and pests Vol. 14; no. 3; pp. 27 - 36
• Main Authors: Wang, Jingchao, Wang, Mingxinzhi, Chen, Hai, Quan, Quan, Huang, Xichun, Jin, Chenghao
• Format: Journal Article
• Language: English
• Published: Cranston Wu Chu (USA-China) Science and Culture Media Corporation 01.06.2023
• Subjects: Antineoplastic drugs; Antitumor activity; Antitumor agents; Apoptosis; Autophagy; Blood vessels; Cancer therapies; Cell cycle; Cell growth; Cell proliferation; Colorectal cancer; Flow cytometry; G phase; Gastric cancer; Liver cancer; Lung cancer; Melanoma; Molecular modelling; Mortality; N-Cadherin; Phosphorylation; Prostate; Protein-tyrosine-phosphatase; Proteins; Skin cancer; Stem cell transplantation; Toxicity; Tumors; Vascular endothelial growth factor
• DOI: 10.19579/j.cnki,plant-d.p.2023.03.009
• ISSN: 2152-3932

The current commonly used chemotherapeutic drugs have such disadvantages as high toxicity and side effects, long treatment cycle and high cost. [...]the search for a kind of efficient, safe and inexpensive natural anticancer drugs is a hot spot of current drug research. Zhang Liyi et al. 191 explored the effect of OP-B on the growth of AGS cells in GC by constructing a nude-mouse transplanted tumor model, and put forward that OP-B could significantly reduce the expression level of GPX4 and xCT proteins in tumor tissue, thus reducing the volume and weight of the transplanted tumor. Gao Guangyi et al. 2 reported that OP-B (20 |janol/l.) could increase the number of HCT-116 cells at G phase , inhibit the proliferation of cancer cells, and induce cell cycle arrest at G phase through flow cytometry and western blot assay. [14] explored the effect of OP-B on the growth of MHCC97-H cells by constructing a nude-mouse transplanted tumor model, and found that OP-B (75 mg/kg) could induce the apoptosis of MHCC97-H cells by down-regulating the expression levels of protein tyrosine phosphatase 1В ( PTPIB) , N-cadherin and vascular endothelial growth factor ( VEGE) , then reduce the viability of MHCC97-H cells, and inhibit the formation of new blood vessels in tumor, ultimately reducing tumor volume and weight in nude mice.