Antitumor Effect and Molecular Mechanism of Ophiopogonin B
The current commonly used chemotherapeutic drugs have such disadvantages as high toxicity and side effects, long treatment cycle and high cost. [...]the search for a kind of efficient, safe and inexpensive natural anticancer drugs is a hot spot of current drug research. Zhang Liyi et al. 191 explore...
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Published in | Plant diseases and pests Vol. 14; no. 3; pp. 27 - 36 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Cranston
Wu Chu (USA-China) Science and Culture Media Corporation
01.06.2023
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Subjects | |
Online Access | Get full text |
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Summary: | The current commonly used chemotherapeutic drugs have such disadvantages as high toxicity and side effects, long treatment cycle and high cost. [...]the search for a kind of efficient, safe and inexpensive natural anticancer drugs is a hot spot of current drug research. Zhang Liyi et al. 191 explored the effect of OP-B on the growth of AGS cells in GC by constructing a nude-mouse transplanted tumor model, and put forward that OP-B could significantly reduce the expression level of GPX4 and xCT proteins in tumor tissue, thus reducing the volume and weight of the transplanted tumor. Gao Guangyi et al. 2 reported that OP-B (20 |janol/l.) could increase the number of HCT-116 cells at G phase , inhibit the proliferation of cancer cells, and induce cell cycle arrest at G phase through flow cytometry and western blot assay. [14] explored the effect of OP-B on the growth of MHCC97-H cells by constructing a nude-mouse transplanted tumor model, and found that OP-B (75 mg/kg) could induce the apoptosis of MHCC97-H cells by down-regulating the expression levels of protein tyrosine phosphatase 1В ( PTPIB) , N-cadherin and vascular endothelial growth factor ( VEGE) , then reduce the viability of MHCC97-H cells, and inhibit the formation of new blood vessels in tumor, ultimately reducing tumor volume and weight in nude mice. |
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ISSN: | 2152-3932 |
DOI: | 10.19579/j.cnki,plant-d.p.2023.03.009 |