Serotonin and emotion regulation: the impact of tryptophan depletion on emotional experience, neural and autonomic activity

• Published in: Cognitive, affective, & behavioral neuroscience Vol. 23; no. 5; pp. 1414 - 1427
• Main Authors: Bîlc, Mirela I, Jacob, Alexandra, Szekely-Copîndean, Raluca D, Kiss, Béla, Ștefan, Maria-Georgia, Mureșan, Raul C, Pop, Claudia Felicia, Pițur, Simina, Szentágotai-Tătar, Aurora, Vulturar, Romana, MacLeod, Colin, Miu, Andrei C
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.10.2023
• Subjects: Amino acids; Antibiotics; Anxiety disorders; Autonomic nervous system; Bayesian analysis; Decision making; Drug abuse; Eating disorders; EEG; Emotional regulation; Emotions; Endocrine disorders; Mental disorders; Neurological diseases; Obsessive compulsive disorder; Psychopathology; Questionnaires; Serotonin; Serotonin uptake inhibitors; Statistical analysis; Tryptophan
• ISSN: 1530-7026; 1531-135X
• DOI: 10.3758/sl3415-023-01116-1

A recent study also has drawn attention to the high individual variability in the response to SSRIs (da Cunha-Bang et al., 2019). Several studies (Choi et al., 2016; Deng et al., 2021) have examined electroencephalographic (EEG) frontal alpha power asymmetry in reappraisal ability tasks. Crucially, we combined traditional frequentist and Bayesian statistical analyses to provide a full account of the data in terms of relative evidence supporting the alternative or the null hypothesis. The following exclusion criteria applied: (1) past or current medical conditions including neurological or endocrine disorders; (2) mental health problems, such as major depressive disorder, anxiety disorder, obsessive-compulsive disorder, eating disorders; (3) current use of antibiotics; (4) current use of psychoactive medication; (5) frequent alcohol abuse; and (5) regular smoking.