Multicomponent Radical Cross‐Coupling Reaction of Propellane: Synthesis of 1‐Arylthiol‐3‐Heteroaryl Bicyclopentanes

Herein, a visible light‐mediated multicomponent radical cross‐coupling reaction of [1.1.1]propellane with N‐heterocycles and disulfides is described. The mild conditions enabled the installation of the BCP motif in a wide variety of compounds in the absence of photocatalyst, additive and metal catal...

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Published inAdvanced synthesis & catalysis Vol. 365; no. 18; pp. 3112 - 3117
Main Authors Li, Lin, Liu, Yumiao, Li, Jian, Chen, Qing, Zhang, Pengfei, Shen, Jiabin, Wu, Jirong
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 01.09.2023
Subjects
Chemical reactions
Chemical synthesis
Cross coupling
Functional groups
Pentanes
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Summary:Herein, a visible light‐mediated multicomponent radical cross‐coupling reaction of [1.1.1]propellane with N‐heterocycles and disulfides is described. The mild conditions enabled the installation of the BCP motif in a wide variety of compounds in the absence of photocatalyst, additive and metal catalyst, with excellent functional group tolerance, This methodology opens a approach for the synthesis of potentially bioactive 1‐arylthiol‐3‐heteroaryl bicyclo[1.1.1]pentanes in moderate to good yield.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202300534