Re-evaluating evidence for adaptive mutation rate variation/Reply
[...]failure to eliminate poor-quality reads and mapping artefacts will overreport clustering of putative mutations. In neither, nor in the merged dataset, is there heterogeneity in the mutation rate between gene classes in coding sequence (CDS) or intron (Fig. 1b and Extended Data Fig. 2). The most...
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| Published in | Nature (London) Vol. 619; no. 7971; pp. E52 - 2 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group
27.07.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | [...]failure to eliminate poor-quality reads and mapping artefacts will overreport clustering of putative mutations. In neither, nor in the merged dataset, is there heterogeneity in the mutation rate between gene classes in coding sequence (CDS) or intron (Fig. 1b and Extended Data Fig. 2). The most common dinucleotide mutations in the Monroe data end AA or TT as the resolved mutational event, with G/C mutated to the neighbouring A/T being especially discrepant (Extended Data Fig. 1f). In (robust) germline data there is a higher mutation rate in TEs than elsewhere, including the best comparator, non-TE intergenic sequence: TE versus non-TE intergenic sequence, mean |
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| AbstractList | [...]failure to eliminate poor-quality reads and mapping artefacts will overreport clustering of putative mutations. In neither, nor in the merged dataset, is there heterogeneity in the mutation rate between gene classes in coding sequence (CDS) or intron (Fig. 1b and Extended Data Fig. 2). The most common dinucleotide mutations in the Monroe data end AA or TT as the resolved mutational event, with G/C mutated to the neighbouring A/T being especially discrepant (Extended Data Fig. 1f). In (robust) germline data there is a higher mutation rate in TEs than elsewhere, including the best comparator, non-TE intergenic sequence: TE versus non-TE intergenic sequence, mean |
| Author | Wang, Long Yang, Sihai Ho, Alexander T Hurst, Laurence D |
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| DOI | 10.1038/s41586-023-06314-y |
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| Snippet | [...]failure to eliminate poor-quality reads and mapping artefacts will overreport clustering of putative mutations. In neither, nor in the merged dataset, is... |
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| Title | Re-evaluating evidence for adaptive mutation rate variation/Reply |
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