Re-evaluating evidence for adaptive mutation rate variation/Reply

[...]failure to eliminate poor-quality reads and mapping artefacts will overreport clustering of putative mutations. In neither, nor in the merged dataset, is there heterogeneity in the mutation rate between gene classes in coding sequence (CDS) or intron (Fig. 1b and Extended Data Fig. 2). The most...

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Bibliographic Details
Published inNature (London) Vol. 619; no. 7971; pp. E52 - 2
Main Authors Wang, Long, Ho, Alexander T, Hurst, Laurence D, Yang, Sihai
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 27.07.2023
Subjects
Clustering
Genes
Genomes
Heterogeneity
Mutation
Mutation rates
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Summary:[...]failure to eliminate poor-quality reads and mapping artefacts will overreport clustering of putative mutations. In neither, nor in the merged dataset, is there heterogeneity in the mutation rate between gene classes in coding sequence (CDS) or intron (Fig. 1b and Extended Data Fig. 2). The most common dinucleotide mutations in the Monroe data end AA or TT as the resolved mutational event, with G/C mutated to the neighbouring A/T being especially discrepant (Extended Data Fig. 1f). In (robust) germline data there is a higher mutation rate in TEs than elsewhere, including the best comparator, non-TE intergenic sequence: TE versus non-TE intergenic sequence, mean
ISSN:0028-0836
1476-4687
DOI:10.1038/s41586-023-06314-y