Synthesis of C‐3‐Functionalized Imidazopyridines via Direct para‐Position Arylation of Electron‐Rich Anilines under Transition‐Metal‐Free Conditions

• Published in: Advanced synthesis & catalysis Vol. 365; no. 13; pp. 2159 - 2164
• Main Authors: Hao, Liqiang, Wu, Gaorong, Wang, Yangyang, Xu, Xiaobo, Ji, Yafei
• Format: Journal Article
• Language: English
• Published: Heidelberg Wiley Subscription Services, Inc 01.07.2023
• Subjects: Aniline; Functional groups; Methylation; Pyridines; Reagents

A multicomponent tandem arylation reaction was established under transition‐metal‐free conditions to synthesize structurally diverse imidazo[1,2‐a]pyridines. As N,N‐dimethylaniline is not only a reactant but also a methylation reagent, its use affords an alternative route for methylation. This appro...