Synthesis of C‐3‐Functionalized Imidazopyridines via Direct para‐Position Arylation of Electron‐Rich Anilines under Transition‐Metal‐Free Conditions

A multicomponent tandem arylation reaction was established under transition‐metal‐free conditions to synthesize structurally diverse imidazo[1,2‐a]pyridines. As N,N‐dimethylaniline is not only a reactant but also a methylation reagent, its use affords an alternative route for methylation. This appro...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 365; no. 13; pp. 2159 - 2164
Main Authors Hao, Liqiang, Wu, Gaorong, Wang, Yangyang, Xu, Xiaobo, Ji, Yafei
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 01.07.2023
Subjects
Aniline
Functional groups
Methylation
Pyridines
Reagents
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Summary:A multicomponent tandem arylation reaction was established under transition‐metal‐free conditions to synthesize structurally diverse imidazo[1,2‐a]pyridines. As N,N‐dimethylaniline is not only a reactant but also a methylation reagent, its use affords an alternative route for methylation. This approach features mild reaction conditions and good functional group tolerance, providing 29 compounds in acceptable yields.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202300347