Studies Leading to Phyto and Physico-chemical Evaluation of an important Polypharmaceutical preparation (Syrup) "Sharbat Toot Siyah"- A Drug of Choice

The drug Sharbat Toot Siyah was in-house manufactured in three batches of different volumes of 500, 600 and 700ml following the SOP guidelines and underwent for the evaluation of secondary metabolite constituents Profile with Physico-chemical Standardization of this important poly-herbal formulation...

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Bibliographic Details
Published inInternational journal of pharmaceutical dosage forms and technology Vol. 15; no. 1; pp. 14 - 18
Main Authors Mustafa, Akhlaq, Hussain, Umar, Alvi, Anas Iqbal, Javed, Ghazala, Khan, Asim Ali
Format Journal Article
LanguageEnglish
Published Raipur A&V Publications 01.01.2023
Subjects
Amino acids
Chromatography
Density
Fruits
Heavy metals
Ingredients
Medicine
Pesticides
Phytochemicals
Quality control
Quality standards
Standardization
Sucrose
Viscosity
Asia
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Summary:The drug Sharbat Toot Siyah was in-house manufactured in three batches of different volumes of 500, 600 and 700ml following the SOP guidelines and underwent for the evaluation of secondary metabolite constituents Profile with Physico-chemical Standardization of this important poly-herbal formulation. Physico and phyto-chemical evaluation of Sharbat Toot Siyah: Physico-chemical parameters e.g. total ash, acid Insoluble ash, alcohol and hexane soluble extractives, pH values of 1 and 10% aqueous solution along with the specific gravity, viscosity, refractive index, sugar estimations were carried out as per the method described in WHO guidelines15. For the chromatographic estimations, thin layer chromatography of ethanol extract was carried outand data of Rf values are reported by following the method on percolated Silica gel 60 F264 TLC plates17-19. Escherichia coli and Total Fungal count (TFC) were not detected while Total Bacterial load and Salmonella spp were found to be within the permissible limit as stated by W H O. Chromatographic estimation Sharbat TootSiyah: Thin Layer Chromatography: Extract of ethanol of the drug was spotted on a precoated silica gel 60 F254 TLC (Merck Germany) as an absorbent and developed the plate using Toluene: Ethyl acetate (8: 2) as a mobile phase.
ISSN:0975-234X
0975-4377
DOI:10.52711/0975-4377.2023.00003_