Evaluation of PD-1 Positive Blood Follicular Helper T Cells in Psoriatic Patients

• Published in: NeuroQuantology Vol. 20; no. 16; p. 2308
• Main Authors: Alaa Hassan Maraee, Reem Ahmed Abd El-Aziz Hassan, Reham Salah El Zaiat, Nancy Ibrahim Attia Shalaby (M B B Ch)
• Format: Journal Article
• Language: English
• Published: Bornova Izmir NeuroQuantology 01.01.2022
• Subjects: Angiogenesis; Antibodies; Cancer; Conflicts of interest; Dermatology; Disease; Immune system; Immunology; Independent sample; Lymphocytes; Medicine; Melanoma; Outpatient care facilities; Pathogenesis; Psoriasis; Skin; Statistical analysis
• ISSN: 1303-5150
• DOI: 10.48047/NQ.2022.20.16.NQ88231

Background:Psoriasis is diagnosed clinically based on characteristic erythematous, well-demarcated, silvery-white scaly papules or plaques over the extensor aspect of the knees, elbows, and trunk as well as the scalp. Objectives: This study aimed to evaluate &analyse the role of PD1 +ve TFH cells in psoriatic patients and its relation to the clinical signs. Methods: The study involved 30 patients with psoriasis from Dermatology outpatient clinic, Menoufia university hospital and 15 apparently healthy volunteers as control group. Results: There is no statistically significant correlation between CD4, CD4/CD18, CD4/CD249, CD185/CD249, PD1 and age, age of onset, duration of illness and PASI score. Conclusion: In conclusion, our finding could explain the paucity of humoral immunity in psoriasis pathogenesis. There is statistically significant increase in CD4 and CD4/CD249 in patients with psoriasis than healthy controls, while there is statistically significant decrease in CD185/CD249 and PD1in patients with psoriasis than healthy controls.