Titelbild: Verwendung der Struktur und Dynamik der Squalen‐Hopen‐Zyklase für die

Ambergris is a highly valued natural product in the fragrance industry and is also known as "floating gold" because of its biosynthesis in the intestines of sperm whales. Owing to this scarce natural resource, the stereoselective synthesis of its most prominent olfactory component, (−)‐amb...

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Bibliographic Details
Published inAngewandte Chemie Vol. 135; no. 22
Main Authors Schneider, Andreas, Curado, Christian, Lystbaek, Thomas B, Osuna, Sílvia, Hauer, Bernhard
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.05.2023
Subjects
Biosynthesis
Chemistry
Intestine
Natural products
Natural resources
Squalene
Stereoselectivity
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Summary:Ambergris is a highly valued natural product in the fragrance industry and is also known as "floating gold" because of its biosynthesis in the intestines of sperm whales. Owing to this scarce natural resource, the stereoselective synthesis of its most prominent olfactory component, (−)‐ambroxide, via alternative routes is attractive. In their Research Article (e202301607), Sílvia Osuna, Bernhard Hauer et al. demonstrate the catalytic potential of an engineered squalene‐hopene cyclase in the intricate cyclization of the precursor homofarnesol. Cover art: Verena Resch, Graz.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202305546