Multicomponent Synthesis of 5‐Cyano‐pyrazolopyrimidines Enabled by Aerobic Manganese Catalysis
An aerobic Mn(III)‐catalyzed one‐pot three‐component synthesis of 5‐cyano‐pyrazolo[1,5‐a]pyrimidines has been described. The synergistic combination of Strecker reaction and oxidatively‐induced 6π‐azacyclization is the key to the success of this multicomponent synthesis. Differing from previous repo...
Saved in:
Published in | Advanced synthesis & catalysis Vol. 365; no. 6; pp. 871 - 876 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Heidelberg
Wiley Subscription Services, Inc
01.03.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | An aerobic Mn(III)‐catalyzed one‐pot three‐component synthesis of 5‐cyano‐pyrazolo[1,5‐a]pyrimidines has been described. The synergistic combination of Strecker reaction and oxidatively‐induced 6π‐azacyclization is the key to the success of this multicomponent synthesis. Differing from previous reports relied on toxic cyanating agents or multistep synthesis, this mechanistically distinct protocol serves as a step‐economic, regioselective and functionally tolerant strategy to obtain 5‐cyano‐pyrazolo[1,5‐a]pyrimidines. |
---|---|
ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.202201361 |