Multicomponent Synthesis of 5‐Cyano‐pyrazolopyrimidines Enabled by Aerobic Manganese Catalysis

An aerobic Mn(III)‐catalyzed one‐pot three‐component synthesis of 5‐cyano‐pyrazolo[1,5‐a]pyrimidines has been described. The synergistic combination of Strecker reaction and oxidatively‐induced 6π‐azacyclization is the key to the success of this multicomponent synthesis. Differing from previous repo...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 365; no. 6; pp. 871 - 876
Main Authors Heng‐Tong Qu, Zeng‐Hui Wu, Guo‐Chen Zhong, Yan‐Chun Zhang, Cheng‐Tao Feng, Xu, Kun
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 01.03.2023
Subjects
Chemical synthesis
Manganese
Pyrimidines
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Summary:An aerobic Mn(III)‐catalyzed one‐pot three‐component synthesis of 5‐cyano‐pyrazolo[1,5‐a]pyrimidines has been described. The synergistic combination of Strecker reaction and oxidatively‐induced 6π‐azacyclization is the key to the success of this multicomponent synthesis. Differing from previous reports relied on toxic cyanating agents or multistep synthesis, this mechanistically distinct protocol serves as a step‐economic, regioselective and functionally tolerant strategy to obtain 5‐cyano‐pyrazolo[1,5‐a]pyrimidines.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202201361