P2X Receptors: Epithelial Ion Channels and Regulators of Salt and Water Transport

When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion channels, P2X receptors, play a specialized role in...

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Bibliographic Details
Published inNephron Vol. 108; no. 3; p. p60
Main Authors Wildman, Scott S P, King, Brian F
Format Journal Article
LanguageEnglish
Published Basel S. Karger AG 01.04.2008
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Summary:When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion channels, P2X receptors, play a specialized role in the regulation of ion and water movement across the renal tubule and are integral to electrolyte and fluid homeostasis. In this short review, we discuss the concept of P2X receptors as regulators of salt and water salvage pathways, as well as acknowledging their accepted role as ATP-gated ion channels. Copyright © 2008 S. Karger AG, Basel [PUBLICATION ABSTRACT]
ISSN:1660-8151
2235-3186