Antibiotic-associated Adverse Drug Events in Hospitalized Children

• Published in: Çocuk enfeksiyon dergisi Vol. 16; no. 3; pp. E198 - E204
• Main Authors: Güzeloǧlu, Eren, Karacı, Mehmet
• Format: Journal Article
• Language: English
• Published: Istanbul Aves Yayincilik Ltd. STI 01.09.2022
• Subjects: Anaphylaxis; Antibiotics; Comorbidity; Hospitalization; Hospitals; Intensive care; Patients; Pediatrics; Sepsis; Urinary tract diseases; Urinary tract infections; Urogenital system
• ISSN: 1307-1068; 1308-5271
• DOI: 10.5578/ced.202297l4

According to the World Health Organization (WHO), "adverse drug reaction (ADR)" is defined as "a response to a drug that is noxious and unintended and occurs at doses normally used in men for the prophylaxis, diagnosis or therapy of disease, or for modification of physiological function" (3). According to WHO data, while the most commonly used oral antibiotics in Europe, where Türkiye is included, have been determined as amoxicillin and combination of amoxicillin/beta lactamase inhibitor, parenteral antibiotics have been found as ceftriaxone and gentamicin (8). Exclusion criteria were prophylactic antibiotic use with no clear cessation date, use of topical or inhaled antibiotics, tuberculosis regimens, and previously existing chronic diseases. Since our intensive care patients receive more antibiotics and have more than one comorbid disease, only patients admitted in the ward were included into the study. [...]all potential ADEs were finalized within the context of the medical history and clinical course of the patient in order to be sure about the fact that each event is probably associated with antibiotics and to eliminate alternative explanations and categorize the ADEs appropriately.