Research progress on the pathological effects of nuclear transcription factor TDP-43 and its application in disease diagnosis and treatment

• Published in: Jie Fang Jun Yi Xue Za Zhi Vol. 47; no. 10; p. 1026
• Main Authors: Jiao YUE, LI, Qin, YANG, Bing, Yu, AN, Xiao-Feng, TANG, Ying-Mei, CHEN, Ke-Ji, LU, WANG, Peng, Gong-Ren, LI, Hai-Feng, PEI
• Format: Book Review
• Language: Chinese
• Published: Beijing People's Military Medical Press 01.01.2022
• ISSN: 0577-7402
• DOI: 10.11855/j.issn.0577-7402.2022.10.1026

Nuclear transcription factor TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA binding protein commonly expressed and highly conserved in evolution. In physiological state, TDP-43, when localized mainly in nucleus and cytoplasm (no more than 30%), may play a physiological role, such as participating in mRNA transcription, splicing, translation, transport and maintaining the stability of mRNA, while its mislocalization in mitochondria might play a corresponding pathological role. Recent researches found that, in addition to produce a marked effect in neurodegenerative diseases, TDP-43 also plays an important role in the pathological process of tumors, male infertility, osteoarthritis (OA) and other diseases. Therefore, the gene expression, subcellular organelle translocation, function and the relationship with diseases of TDP-43 have attracted more and more attention. The research progress of pathological effects of TDP-43 has been reviewed in present paper, so as to provide more help for diagnosis and treatmen