From stem cells to embryo models in the laboratory

Mouse embryonic stem cells (mESCs) isolated from blastocysts can be maintained in culture7,8 and coaxed to generate specific cell lineages. The larger size of human embryos might mean that embryos depend more heavily than do mouse embryos on the placenta and vascular system - these properties could...

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Bibliographic Details
Published inNature (London) Vol. 610; no. 7930; pp. 39 - 40
Main Authors Amin, Neal D, Pasca, Sergiu P
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 06.10.2022
Subjects
Animal models
Blastocysts
Cell culture
Cell size
Eggs
Embryo cells
Embryogenesis
Embryonic growth stage
Embryos
Gas exchange
Sperm
Stem cell transplantation
Stem cells
Transcription factors
Vascular system
United States > US
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Summary:Mouse embryonic stem cells (mESCs) isolated from blastocysts can be maintained in culture7,8 and coaxed to generate specific cell lineages. The larger size of human embryos might mean that embryos depend more heavily than do mouse embryos on the placenta and vascular system - these properties could inherently limit in vitro development, which depends on diffusion for nutrient and gas exchange. Because human development takes several times as long to reach a stage equivalent to E8.5, generating human embryoids to late stages will be more costly and less feasible. Progress in these areas will undoubtedly advance our understanding of human embryonic development, improve our ability to generate disease-relevant cell types from stem cells and study the factors that affect pregnancy.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-022-03075-y