A blistering cutaneous lesion in an infant

Mastocytoses are a heterogeneous group of disorders characterised by an accumulation of mast cells in tissues.1 Mastocytoses are rare, with an estimated prevalence of 1:10,000.2 They are broadly classified into two groups: cutaneous mastocytosis (CM) and systemic mastocytosis (SM), which also encomp...

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Bibliographic Details
Published inAustralian family physician Vol. 51; no. 10; pp. 769 - 772
Main Authors Willems, Anneliese, Scardamaglia, Laura, Robertson, Susan
Format Journal Article
LanguageEnglish
Published Sydney Copyright Agency Limited (Distributor) 01.10.2022
Subjects
Asymptomatic
Biopsy
Case reports
Children & youth
Dermatology
Hospitals
Hypotension
Immunology
Impetigo
Parasitic diseases
Pediatrics
Urticaria
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Summary:Mastocytoses are a heterogeneous group of disorders characterised by an accumulation of mast cells in tissues.1 Mastocytoses are rare, with an estimated prevalence of 1:10,000.2 They are broadly classified into two groups: cutaneous mastocytosis (CM) and systemic mastocytosis (SM), which also encompass non-cutaneous organ-specific disease.1 CM accounts for 90% of mastocytoses in children3 and has three paediatric subtypes: urticaria pigmentosa, diffuse cutaneous mastocytosis and cutaneous mastocytoma (Table 1).4 Mastocytomas account for 10-15% of paediatric cases of cutaneous mastocytosis and typically present in otherwise well children.5 Mastocytomas usually present in early infancy.5 They are most common on the trunk and extremities but can appear on any part of the body.6 Typically, they are 1-5 cm in diameter, oval in shape and yellow-brown, and they have a peau d'orange appearance. Differentials to consider for solitary blistering skin lesions in childhood include bullous insect bite reaction, bullous impetigo, allergic contact dermatitis and, less commonly, bullous fixed drug eruption.1 When multiple blistered lesions are present, further differentials to consider are scabies and rare conditions such as epidermolysis bullosa and linear immunoglobulin A bullous dermatosis (Table 2).1 In cases of cutaneous mastocytoma, it is important to exclude more widespread disease.
ISSN:2208-7958