Traditional Chinese Medicine Combined with Chemotherapy in Prevention and Treatment of Recurrence and Metastasis of Locally Advanced Gastric Cancer After Radical Resection: A Meta-analysis

Objective To explore the efficacy and safety of traditional Chinese medicine(TCM) combined with chemotherapy in the prevention and treatment of postoperative recurrence and metastasis of locally advanced gastric cancer (LAGC) by meta-analysis. Moreover, we evaluated the efficacy of TCM on the qualit...

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Bibliographic Details
Published inZhongliu fangzhi yanjiu Vol. 49; no. 9; p. 913
Main Authors Wang, Yue, Zhao, Weizhe, Li, Xiaojie, Nan, Mengdie, Xie, Meiwen, Li, Peijin, Hou, Li
Format Journal Article
LanguageChinese
Published Tianjin China Anti-Cancer Association 01.09.2022
Subjects
Cancer
CD3 antigen
CD4 antigen
CD8 antigen
Chemotherapy
Chinese medicine
Clinical trials
Diarrhea
Effectiveness
Gastric cancer
Hemoglobin
Herbal medicine
Leukopenia
Meta-analysis
Metastases
Metastasis
Nausea
Neurotoxicity
Prevention
Quality of life
Renal function
Side effects
Surgery
Thrombocytopenia
Traditional Chinese medicine
Vomiting
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Summary:Objective To explore the efficacy and safety of traditional Chinese medicine(TCM) combined with chemotherapy in the prevention and treatment of postoperative recurrence and metastasis of locally advanced gastric cancer (LAGC) by meta-analysis. Moreover, we evaluated the efficacy of TCM on the quality of life, immune indexes, and toxic and side effects during adjuvant chemotherapy. Methods The CNKI, Wanfang, PubMed, and other databases were searched by computer. Randomized controlled trials (RCTs) were searched. After literature screening and data extraction, Review Manager 5.3 software provided by Cochrane was used for meta-analysis. Results A total of 18 RCTs were included. Compared with chemotherapy alone, TCM combined with chemotherapy could improve the KPS score and CD3+ and CD4+/CD8+ index levels. The incidence rates of postoperative leucopenia, hemoglobin reduction, thrombocytopenia, nausea and vomiting, diarrhea, and neurotoxicity were reduced. In terms of postoperative QLQ-C30 score, abnormal liver fu
ISSN:1000-8578
DOI:10.3971/j.issn.1000-8578.2022.22.0012