Research Progress on Pharmacological Effects of Shikonin Compound β-acetoxyisovalerylalkannin

[...]it is urgent to develop an efficient, safe and inexpensive natural anticancer drug. The results showed that ß-acetoxyisovalerylalkannin inhibited the growth of Kyse 140 and Eca 109 cells in a concentration-dependent manner. [...]with the prolongation of the treatment time and the increase of th...

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Bibliographic Details
Published inMedicinal plant Vol. 13; no. 2; pp. 1 - 7
Main Authors Wang, Anqi, Jin, Chenghao
Format Journal Article
LanguageEnglish
Published Cranston Wu Chu (USA-China) Science and Culture Media Corporation 01.04.2022
Subjects
Annexin V
Antitumor agents
Apoptosis
Breast cancer
Cell cycle
Cell division
Cell growth
Chemotherapy
Edema
Esophageal cancer
Feng Wei
Gastric cancer
Histamine
Kinases
Lung cancer
MAP kinase
Medical prognosis
Melanoma
Ovarian cancer
Permeability
Proteins
Shikonin
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Summary:[...]it is urgent to develop an efficient, safe and inexpensive natural anticancer drug. The results showed that ß-acetoxyisovalerylalkannin inhibited the growth of Kyse 140 and Eca 109 cells in a concentration-dependent manner. [...]with the prolongation of the treatment time and the increase of the dose of ß-acetoxyisovalerylalkannin, the inhibitory effect on cell growth was enhanced. [...]it could be seen that PI + cells and Annexin V + /PI + cells were mainly dead cells after apoptosis of SKOV3 and A2780 cells was induced by ß-acetoxyisovalerylalkannin. LEE et al. &12' detected the apoptosis rate of human melanoma cell line A375SM by Annexin V/PI double staining and found that ß-acetoxyisovalerylalkannin increased the expression of pro-apoptotic protein and decreased the expression of anti-apoptotic protein, thus inducing apoptosis of human melanoma A375SM cells and reducing the tumor volume of mouse transplanted tumor ( A375SM ) model through MAPK signal pathway.
ISSN:2152-3924
DOI:10.19600/j.enki.issn2152-3924.2022.02.001