Raman Spectroscopy in Reverse Engineering

Raman spectroscopy can solve some of the problems in reverse engineering analysis, such as the crystal identification of active ingredients (API), the determination of ingredients in the original preparation, and the analysis of process parameters, such as API distribution, coating layer thickness,...

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Bibliographic Details
Published inJournal of pharmaceutical sciences and research Vol. 14; no. 7; pp. 776 - 782
Main Authors Sri, K Bhavya, Begum, Samreen, Swethasri, R, Sumakanth, Mogili
Format Journal Article
LanguageEnglish
Published Cuddalore Journal of Pharmaceutical Sciences and Research 01.07.2022
Subjects
Defective products
Generic drugs
Ingredients
Lasers
Light
Manufacturing
Pharmaceuticals
Radiation
Reverse engineering
Spectrum analysis
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Summary:Raman spectroscopy can solve some of the problems in reverse engineering analysis, such as the crystal identification of active ingredients (API), the determination of ingredients in the original preparation, and the analysis of process parameters, such as API distribution, coating layer thickness, coating layer number, production process, and spatial distribution related to dissolution characteristics Keywords: Deformulation, Detectors, Raman spectroscopy, Sources, Sample illumination system. The FDA, however, won't give it out to any generics company because it considers the innovator's formula proprietary. Because of this the generic company lacks the guidance and creates the need for pharmaceutical reverse engineering to prove bioequivalence and discover a manufacturing method for the new medication [4] Levels of Pharmaceutical Reverse Engineering are: An alternate in polarizability at some point of molecular vibration is a critical requirement to achieve the Raman spectrum of the sample. Because Raman scattering because of water is low, water is an ideal solvent for dissolving samples. Source: Modern Raman spectroscopy nearly always involves the use of lasers as excitation light sources. Because lasers were not available until more than three decades after the discovery of the effect, Raman and Krishnan used a mercury lamp and photographic plates to file spectra.
ISSN:0975-1459