Effect of Probiotics in the Treatment of Acute Watery Diarrhoea in Children Admitted to a Tertiary Care Hospital in Bangladesh: A Non-Randomized Prospective Clinical Trial

CTRI/2020/04/024633, Date: 15/04/2020 Keywords: Lactobacillus * Bifidobacterium * Acute watery diarrhoea * Probiotics * Clinical trials Introduction Diarrhoeal disease is responsible for a substantial health-related burden on human society and remains the second leading cause of death in children be...

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Bibliographic Details
Published inInternational journal of collaborative research on internal medicine & public health Vol. 14; no. 2; pp. 1 - 6
Main Authors Mosaddek, Abu Syed Md, Rizvi, M Rinat, Akter, Rumi, Islam, Md Saiful, Hossain, Md Nurul, Iqbal, Hrishik, Gazal, David, Islam, Md Salequl, Farhana, Fatima
Format Journal Article
LanguageEnglish
Published Sarajevo DRUNPP Association 01.01.2022
Subjects
Antibiotics
Campylobacter
Children & youth
Clinical trials
Diarrhea
E coli
Enrollments
Gastroenteritis
Hospitals
Immunoglobulins
Microorganisms
Pathogens
Pediatrics
Probiotics
Rotavirus
Viruses
Bangladesh
Europe
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Summary:CTRI/2020/04/024633, Date: 15/04/2020 Keywords: Lactobacillus * Bifidobacterium * Acute watery diarrhoea * Probiotics * Clinical trials Introduction Diarrhoeal disease is responsible for a substantial health-related burden on human society and remains the second leading cause of death in children below 5 years of age. Diarrhoea consists in the symptomatic presentation of acute gastroenteritis, commonly caused by infectious agents, such as viruses (Rotavirus, Norovirus), bacterial pathogens (Escherichia coli, toxigenic Clostridium difficile, Campylobacter jejuni and Vibrio cholerae) and parasites. The ESPGHAN/ESPID evidence-based guidelines for the management of acute gastroenteritis in children in Europe summarized data from several meta-analyses, and reported a significant effect and moderate clinical benefit of selected probiotic strains in the treatment of acute watery Diarrhoea (primarily rotavirus), mainly in infants and young children [12]. Materials and methods Participants This study was performed as a parallel-group, interventional non-randomized study with enrollment of pediatric patients according to eligibility criteria and being allocated to receive probiotic therapy (Group A), conventional antibiotic treatment (Group B), and probiotic + antibiotic therapy (Group C) during the period of April, 2020 to July, 2020 at the Pediatric Department of Uttara Adhunik Medical College & Hospital in Bangladesh.
ISSN:1840-4529
DOI:10.35248/1840-4529.22.14.341