Anti-obesity effect of radish leaf extracts on high fat diet-induced obesity in mice

The goal of this study was to evaluate the anti-obesity effect of radish leaf extracts (MU-C) and radish leaf extracts with 3% citric acid (MU-CA) in a high-fat diet (HFD)-induced C57BL/6 mice. The effects of radish leaf extracts on adipogenesis were also investigated using 3T3-L1 adipocytes. As det...

Full description

Saved in:
Bibliographic Details
Published inHan'guk Sikp'um Kwahakhoe Chi = Korean Journal of Food Science and Technology Vol. 54; no. 3; p. 297
Main Authors Lee, Yun-Seong, Seo, Young Ho, Kim, Ji Yong
Format Journal Article
LanguageEnglish
Korean
Published Seoul Korean Society of Food Science & Technology 01.06.2022
Subjects
Adipocytes
Adipogenesis
Adipose tissue
Alanine
Alanine transaminase
Aspartate aminotransferase
Cholesterol
Citric acid
Diet
Enzyme-linked immunosorbent assay
High fat diet
Leaves
Obesity
Plant extracts
Radishes
Serum levels
Tissue analysis
Transaminases
Triglycerides
Online AccessGet full text

Cover

More Information
Summary:The goal of this study was to evaluate the anti-obesity effect of radish leaf extracts (MU-C) and radish leaf extracts with 3% citric acid (MU-CA) in a high-fat diet (HFD)-induced C57BL/6 mice. The effects of radish leaf extracts on adipogenesis were also investigated using 3T3-L1 adipocytes. As determined by Oil red O staining, MU-C inhibited adipogenesis in 3T3-L1 adipocytes. Four-week-old male C57BL/6 mice were fed an HFD for 6 weeks and then treated with radish leaf extracts (500 mg/kg, p.o.) for 6 weeks. Then, the serum levels of Aspartate aminotransferase, Alanine aminotransferase, Total cholesterol, Triglyceride and low-density lipoprotein cholesterol in the mice were measured using an automatic chemical analyzer and enzyme-linked immunosorbent assay. Administration of MU-C significantly reduced the fat weight when compared with HFD controls. As confirmed by histopathologic analysis, adipose tissue size markedly decreased in mice treated with MU-C. Therefore, this study could provide a basis for investigating the clinical use of MU-C as an agent for preventing obesity.
ISSN:0367-6293
DOI:10.9721/KJFST.2022.54.3.297