On the robustness of the in vivo cyanobacterial circadian clock

We propose a revisited version of the in vivo model of the cyanobacterial circadian clock. Our aim is to address the lack of robustness predicted for the mutant cyanobacteria without transcriptional regulation of the original model. For this, we rely on an in vitro model of the clock describing expl...

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Bibliographic Details
Published inarXiv.org
Main Authors Dorota Youmbi Fouego, de Buyl, Sophie
Format Paper
LanguageEnglish
Published Ithaca Cornell University Library, arXiv.org 08.04.2022
Subjects
Biological clocks
Circadian rhythm
Cyanobacteria
Robustness
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Summary:We propose a revisited version of the in vivo model of the cyanobacterial circadian clock. Our aim is to address the lack of robustness predicted for the mutant cyanobacteria without transcriptional regulation of the original model. For this, we rely on an in vitro model of the clock describing explicitly the hexameric structure of the core protein of the clock. Our model is able to reproduce oscillatory behavior for the mutant, as observed experimentally, without finely tuned parameters.
ISSN:2331-8422