Polyfunctional Multitarget Drugs as a Basis of Pharmacology of the 21st Century

Due to the fact that all diseases began to be considered as multifactorial, the main direction of pharmacology in the 21st century is the design of multitarget ligands. The relevance of this approach is confirmed by the authors’ research in the field of analysis of thespectrum of affinity for nine i...

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Published inVestnik Volgogradskogo gosudarstvennogo universiteta, Serii͡a︡ 11, Estestvennye nauki Vol. 8; no. 1
Main Authors Vasilyev, Pavel M, Kosolapov, Vadim A, Spasov, Aleksandr A, Yanalieva, Laura R
Format Journal Article
LanguageRussian
Published Volgograd Volgograd State University 01.01.2018
Subjects
21st century
Affinity
Arrhythmia
Drugs
Glycosylation
Ion channels
Ligands
Pharmacology
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Summary:Due to the fact that all diseases began to be considered as multifactorial, the main direction of pharmacology in the 21st century is the design of multitarget ligands. The relevance of this approach is confirmed by the authors’ research in the field of analysis of thespectrum of affinity for nine ion channels of the heart for three antiarrhythmic drugs, as well as the results of initiatory research into the search for fundamentally new multifunctional multitarget inhibitors of glycation end-product receptors.
ISSN:2306-4153
2409-2762
DOI:10.15688/jvolsu11.2018.1.6