Synthesis, spectroscopic, Thermal and antibacterial assay for Azothiobutricacidligand and Co (ΙΙ), Ni (ΙΙ) and Cu (ΙΙ) complexes

• Published in: Annals of the Romanian society for cell biology Vol. 25; no. 6; pp. 5059 - 5073
• Main Authors: Abbas, Alyaa Khider, Kadhim, Rafal Salam
• Format: Journal Article
• Language: English
• Published: Arad "Vasile Goldis" Western University Arad, Romania 01.01.2021
• Subjects: Antibacterial activity; Bacillus; Benzene; Copper; Dyes; Ethanol; Geometry; Ligands; Metal ions; NMR; Nuclear magnetic resonance; Solvents
• ISSN: 2067-3019; 2067-8282

On complexes this band was changed in the shape andpositionso this assignable to thebrokingof hydrogen bond byeffect of metal ion. b. The bond was attributed to U (N-H) in pyrimidine moiety is observed at (3166 cm-1) don'teffected on coordination when compared the spectra of all complexes with the spectrum of thefreeligand [4]. c. The strong triplet bond appeared in the (DMAT) spectrum at (1693, 1649, 1625) cm" wereassignedtoUC-0)ofketoform.Thegreatshiftofthe(CO)stretchingfrequencyinthespectrumcoordination [10] (Table 2). of the prepared complexes which indicates the (C-0) group one oftheparties to coordination [10][Table 2]. d. Anothersiteofchelationisazogroup.thisbondwasappearedascheletbandsat(1413,1361)cm-1 in the spectrum of the (DMAT) belong to U(N=N), the shape of this band were changed andshifted to low frequency as was shown in Table (2) Change in the stretching frequencies of theazogroup suggestinginvdement ofthisgroupincoordination with metalions[4,9]. e. A band was attributed to U(C=S) was appeared at (1217) cm-1 in the spectrum at the free ligandandthisbandappeared atapproximatelyinthesamerange,which willindicatingthatdiol notenterin complexation[11]. f. Anumberofnewbandnotpresentinthespectrumoffreeligandwereseen,however,themostnoticeable change are in the range (450-200) cm-1 region the weak band were appeared in thisregion may belogs to U(M-O), U(M-N) and U(M-Cl) . NMRSpectrum: 1H NMR spectrum of the freeligand (DMAT) inDMSO has showen proton signals at 3.04, 9.63 and(7.45-7.81) ppm corresponding to the methyl moiety benzene ring, (N-H) on pyrimidine moiety forthiobarbituricacid and toprotons in benzeneringrespectively[14] AntibacterialEffect: The capacity of antibacterial activity of the four newly synthesized compounds against four types ofbacteria (Staphylococcus bacteria, Escherichia coli, Proteus Mirabilius and Bacillus). The result shows that the synthetizedcompounds showed higher antimicrobial activities than those of standard except Bacillus. [...]inthepresentworkallsynthesizedcompoundspossessedstrong,moderate,and strongactivitiesagainstalltestbacteria.