Ciliated muconodular papillary tumour of the lung mimicking mucinous adenocarcinoma: a case report and literature review

Follow-up CT scan 1 year later revealed minimal increase in size to 10 mm and the patient was referred to the Department of Thoracic Surgery, University of Hong Kong[-]Shenzhen Hospital in November 2015 for further treatment. Examination of the lobectomy specimen showed focal peribronchiolar fibrosi...

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Published inHong Kong medical journal = Xianggang yi xue za zhi Vol. 25; no. 1; p. 71
Main Authors Cheung, Florence MF, Guan, J, Luo, Q G, Sihoe, Alan DL, ir, Shen, X P
Format Journal Article
LanguageChinese
English
Published Hong Kong Hong Kong Academy of Medicine 01.02.2019
Subjects
Ethics
Laryngeal cancer
Medical imaging
Mutation
Pathogenesis
Patients
Smoking
Thoracic surgery
Tumors
Hong Kong
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Summary:Follow-up CT scan 1 year later revealed minimal increase in size to 10 mm and the patient was referred to the Department of Thoracic Surgery, University of Hong Kong[-]Shenzhen Hospital in November 2015 for further treatment. Examination of the lobectomy specimen showed focal peribronchiolar fibrosis compatible with the effect of smoking.1 These foci often contained peribronchiolar metaplasia featuring ciliated and mucinous columnar cells (Fig f) occasionally forming small papillae (Fig f, inset). [...]reports by Ishikawa2 and others3 4 5 6 7 of similar tumours under various names (eg, solitary peripheral ciliated glandular papillomas, peripheral pulmonary papillary/glandular neoplasms with ciliated cells) supported this group of tumours as a specific entity that has not been included in the 2015 World Health Organization Classification of Lung Tumours.8 We searched the literature and reviewed 12 reports of 33 such tumours (online supplementary Appendix). [...]Kamata et al7 reported mutations involving EGFR,
ISSN:1024-2708
2226-8707
DOI:10.12809/hkmj165032