Phylogenetic and sequence profile analysis of NonRibosomal Polyketide Synthase-Adenylation (NRPS) domain from Actinobacterium dagang 5

This study aims to find out the mapping of bioactive compounds by combinational analysis of regulatory machinery pattern study and metabolomics approach. In which we isolated a highly potent Actinobacterium dagang 5 from Gulf of Manner, which shows broadspectrum activity against several pathogens. S...

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Bibliographic Details
Published inBioinformation Vol. 17; no. 9; p. 809
Main Authors Thandayuthapani, Deepika, Chinnappa, Nivetha, Annavi, Arjunan, Manickam, Muthusevam
Format Journal Article
LanguageEnglish
Published Puducherry Biomedical Informatics 01.09.2021
Subjects
Adenylation
Antibacterial materials
Bioactive compounds
Biological activity
Domains
Gene clusters
Metabolites
Metabolomics
Pattern analysis
Phylogeny
Polyketide synthase
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Summary:This study aims to find out the mapping of bioactive compounds by combinational analysis of regulatory machinery pattern study and metabolomics approach. In which we isolated a highly potent Actinobacterium dagang 5 from Gulf of Manner, which shows broadspectrum activity against several pathogens. So the isolate was used for overall metabolic profiling studies on crude extract and phylogeny pattern analysis of NRPS A-domain, which is an important gene clusters and plays vital role in production of bioactive metabolites. The result suggests that Actinobacterium dagang 5 has the potential to produce a new type of antibacterial compounds.
ISSN:0973-8894
0973-2063
DOI:10.6026/97320630017809