HLA-DQ Genotyping of Celiac Disease among Syrian patients

SUBJECTS & METHODS Study design and population The Ethics Committee of Damascus University in Syria had approved the protocol of this study and all participants submitted written informed consents prior to the commencement of this study. For the control group, 100 healthy subjects corresponding...

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Bibliographic Details
Published inAnnals of the Romanian society for cell biology Vol. 25; no. 5; pp. 4926 - 4936
Main Authors Alhabbal, Adel, Khamis, Imad Abou
Format Journal Article
LanguageEnglish
Published Arad "Vasile Goldis" Western University Arad, Romania 01.01.2021
Subjects
Anemia
Antigens
Autoimmune diseases
Celiac disease
Disease
DQA1 protein
Genotype & phenotype
Genotyping
Gluten
Haplotypes
Histocompatibility antigen HLA
Pediatrics
Population studies
Serology
Syria
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Summary:SUBJECTS & METHODS Study design and population The Ethics Committee of Damascus University in Syria had approved the protocol of this study and all participants submitted written informed consents prior to the commencement of this study. For the control group, 100 healthy subjects corresponding in age(22 ±14) and gender (51 Males and 49 females) to the case group, with no previous systematic diseases and with the absence of previously diagnosed celiac disease, cancer, gastrointestinal complains or autoimmune disorders. [...]detecting the expression of (DQA1·05, DQB1·02) HLA DQ2 and (DQB1·03:02, HLA-DQA1·0301) provides a great tool to exclude the presence of CeD in dubious individuals. [...]these HLA-DQ2 variants have a large frequency in France (87%), Italy (84%), and UK (88%) CD patients (26).
ISSN:2067-3019
2067-8282