Assessment of Adverse Drug Reactions in the Diagnosed ADR Patients

• Published in: Annals of the Romanian society for cell biology Vol. 24; no. 2; pp. 691 - 695
• Main Authors: Sahu, Rimjhim, Jain, Mahesh Kumar, Raja, Mustafa, Nagpure, Shailesh
• Format: Journal Article
• Language: English
• Published: Arad "Vasile Goldis" Western University Arad, Romania 01.01.2020
• Subjects: Abuse; Cardiovascular system; Data analysis; Diagnosis; Drug dosages; Emergency medical care; Ethics; Hospitalization; Patients; Prophylaxis; Teaching hospitals
• ISSN: 2067-3019; 2067-8282

Introduction: According to WHO, an adverse drug reaction was originally defined in 1972 as a response to a drug that is noxious and unintended and occur at doses normally used in humans for the prophylaxis, diagnosis, or therapy of disease, or for modification of any physiological function.1 An adverse drug reaction (ADR) can be defined as "an appreciably harmful or unpleasant reaction resulting from an intervention related to the use of a medicinal product; adverse effects usually predict hazard from future administration and warrant prevention, or specific treatment, or alteration of the dosage regimen, or withdrawal of the product'.2 Since 2012, the definition has included reactions occurring as a result of error, misuse or abuse, and to suspected reactions to medicines that are unlicensed or being used off-label in addition to the authorised use of a medicinal product in normal doses.3 ADRs are of major concern in patients with complex therapeutic regimens. From the literature it is observed that 5% of all hospital admissions were related to druginduced problems and 10-20% of hospitalized patients are developing ADRs, it is estimated that ADRs are the fourth to the sixth leading cause of death.9 In this cross sectional study a sample of 220 patient were taken. Using the Naranjo's algorithm, 60.93% of the ADRs were defined as "probable," whereas 38.12% were defined as "possible" and 0.93% were classified as "definite" in relation to the suspected drug.10 A study conducted by Suh et al, which revealed that the system most badly affected was the dermatological and gastrointestinal system.11 An Italian study surveying patients admitted through the emergency department to three hospitals found an initial diagnosis of an ADR in 21.2% of patients but 98% of those were deemed predictable and were not further analysed.12 Murphy and Frigo developed and implemented an ADR reporting program in Loyola University Medical Center, a 563-bed tertiary care teaching hospital located in the western suburbs of Chicago. Shanmugam H, Panneerselvam N, Lawrence A. Adverse drug reactions of cardiovascular drugs in intensive cardiac care unit in a tertiary care hospital: A prospective study.