The Effect of Exercise Capacity on Metabolic and Cardiac Aging in Normal and Obese Rats

Exercise capacity predicts metabolic and cardiac aging. However, mechanisms that mediate the effect of exercise capacity on metabolic and cardiac aging have never been holistically identified in both normal condition and obesity-induced premature aging. Seven-week-old male Wistar rats received eithe...

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Published inDiabetes (New York, N.Y.) Vol. 70
Main Authors Thonusin, Chanisa, Pantiya, Patcharapong, Sumneang, Natticha, Sriwichaiin, Sirawit, Chattipakorn, Nipon, Chattipakorn, Siriporn C
Format Journal Article
LanguageEnglish
Published New York American Diabetes Association 01.06.2021
Subjects
Aging
Apoptosis
Calorimetry
Diabetes
Dyslipidemia
Echocardiography
Exercise
Heart
High fat diet
Insulin
Insulin resistance
Metabolism
Mitochondria
Obesity
Oxidation
Rodents
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Summary:Exercise capacity predicts metabolic and cardiac aging. However, mechanisms that mediate the effect of exercise capacity on metabolic and cardiac aging have never been holistically identified in both normal condition and obesity-induced premature aging. Seven-week-old male Wistar rats received either a normal diet (n = 6) or a high-fat diet (HFD; n = 6). At week 12 and 28, the rats were run on a treadmill to measure exercise capacity. Plasma metabolic profiles, indirect calorimetry, and echocardiography were done at week 28. Heart tissues at week 28 were then obtained after sacrifice. From week 12 to 28, the rats developed aging as indicated by decreased exercise capacity. Exercise capacity at week 12 revealed positive correlations with favorable metabolic and cardiac profiles, but exhibited negative correlations with adverse metabolic and cardiac profiles at week 28 (Table). Interestingly, the number of correlated parameters was greater in HFD-fed rats (Table). All of these findings suggest that exercise capacity has protective effect against metabolic aging via attenuation of impaired substrate oxidation, obesity, insulin resistance, and dyslipidemia. In addition, exercise capacity has the protection against cardiac aging via ameliorating impaired cardiac mitochondria, inflammation, apoptosis, and systolic dysfunction. Interestingly, these protective effects become highly potent in obese condition.
ISSN:0012-1797
1939-327X
DOI:10.2337/db21-499-P