A screening for the candidate diseases that could benefit from immunotherapy

Objective: Genomic instability is one of the hallmarks of cancer and has seen an increased interest in the last decades due to its capability to predict the response to immunotherapy. The aim of the current study was to determine the microsatellite instability (MSI) on a local cohort and, on the dis...

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Bibliographic Details
Published inHuman & veterinary medicine Vol. 13; no. 2; pp. 67 - 69
Main Authors Pitu, Flaviu, Pasca, Sergiu, Curca, Razvan, Hajjar, Nadim Al
Format Journal Article
LanguageEnglish
Published Cluj-Napoca Bioflux SRL 01.06.2021
Subjects
Cancer therapies
Clinical trials
Colon cancer
Colorectal cancer
Drugs
Endometrium
Gastric cancer
Genomic instability
Hospitals
Immunotherapy
Medical prognosis
Medicine
Melanoma
Metastases
Metastasis
Microsatellite instability
Patients
Pharmacy
Surgery
Survival analysis
Romania
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Summary:Objective: Genomic instability is one of the hallmarks of cancer and has seen an increased interest in the last decades due to its capability to predict the response to immunotherapy. The aim of the current study was to determine the microsatellite instability (MSI) on a local cohort and, on the diseases that present Microsatellite Instability High (MSI-H), to further evaluate the efficacy of these drugs on a publicly available cohort. Material and Method: This was a cross-sectional, observational and analytical study in which we included the patients from our institution and also from the TMB and Immunotherapy online cohort. Results: In the current study we observed that the most relevant cases for which we could implement immunotherapy in the treatment of MSI high patients are represented by the colon cancer cases. This is supported by the fact that colon cancer patients represent the highest percentage of malignancies we treat in our unit, which have a clinically relevant prevalence of MSI high. Conclusion: Thus, in the current study we observed that immunotherapy might be a useful tool in the treatment of metastatic colon cancer in our unit.
ISSN:2066-7655
2066-7663