Molecular Mechanisms for Regulationof Neutrophil Apoptosis under Normal and Pathological Conditions

Neutrophils are one of the main cells of innate immunity that perform a key effector and regulatory function in the development of the human inflammatory response. Apoptotic forms of neutrophils are important for regulating the intensity of inflammation and restoring tissue homeostasis. This review...

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Bibliographic Details
Published inJournal of evolutionary biochemistry and physiology Vol. 57; no. 3; pp. 429 - 450
Main Authors Noseykina, E M, Schepetkin, I A, Atochin, D N
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.01.2021
Subjects
Apoptosis
Cytokines
Homeostasis
Inflammation
Innate immunity
Integrins
Leukocytes (neutrophilic)
Life span
Molecular modelling
Neutrophils
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Summary:Neutrophils are one of the main cells of innate immunity that perform a key effector and regulatory function in the development of the human inflammatory response. Apoptotic forms of neutrophils are important for regulating the intensity of inflammation and restoring tissue homeostasis. This review summarizes current data on the molecular mechanisms of modulation of neutrophil apoptosis by the main regulatory factors of the inflammatory response—cytokines, integrins, and structural components of bacteria. Disturbances in neutrophil apoptosis under stress are also considered, molecular markers of changes in neutrophil lifespan associated with various diseases and pathological conditions are presented, and data on pharmacological agents for modulating apoptosis as potential therapeutics are also discussed.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093021030017