Effect of Bryophyllum pinnatum Leaves Ethanol Extract in TNF-α and TGF-β as Candidate Therapy of SLE in Pristane-Induced SLE BALB/c Mice Model

Whereas TGF-β is an anti-inflammatory cytokine in innate and adaptive immune responses that has a role in inhibiting proliferation and effector function of T cells, inhibiting proliferation of B cells, inhibiting IgA production, inhibiting macrophage activation, and increasing collagen synthesis by...

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Published inResearch journal of pharmacy and technology Vol. 14; no. 2; pp. 1069 - 1072
Main Authors Nurdiana, Dantara, Tri Wahyudi Iman, Syaban, Mokhamad Fahmi Rizki, Mustafa, Siti Asyifa, Ikhsani, Hanifah, Syafitri, Febrinda Esti, Hapsari, Novi Kurnia, Khoirunnisa, Auliya
Format Journal Article
LanguageEnglish
Published Raipur A&V Publications 01.02.2021
Subjects
Alopecia
Arthritis
Ascites
Baldness
Cell growth
Cytokines
Drug dosages
Ethanol
Flavonoids
Immune system
Inflammation
Laboratories
Lupus
Lymphocytes
Pathogenesis
Rodents
Systems stability
Tumor necrosis factor-TNF
East Java Indonesia
Indonesia
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Summary:Whereas TGF-β is an anti-inflammatory cytokine in innate and adaptive immune responses that has a role in inhibiting proliferation and effector function of T cells, inhibiting proliferation of B cells, inhibiting IgA production, inhibiting macrophage activation, and increasing collagen synthesis by fibroblasts. The results of this study indicate that TGF-β levels of BALB/c mice serum in positive control group induced by pristane is significantly different from those of BALB/c mice in negative control group. The results of this study showed that the administration of ethanol extract of Bryophyllum pinnatum leaves was able to significantly increase serum TGF-β levels of balb/c mice at doses of 21 mg/kg BW and 42 mg/kg BW compared to balb/c mice in the control positive group. Increased levels of TGF-β can be thought to occur due to an increase in Treg cells, according to the research conducted by Indriyanti et al. where the administration of ethyl acetate fraction of Bryophyllum pinnatum has the ability to slightly reduce the levels of anti-Sm antibodies, and increase the percentage of CD4+ CD25+ regulator T cell, so that the immune system stability in lupus can be maintained10.
ISSN:0974-3618
0974-306X
DOI:10.5958/0974-360X.2021.00192.X