Clinical diagnostic value of dickkopf-1 test for menopausal women with rheumatoid arthritis secondary to osteoporosis

Objective　To explore the clinical diagnostic value of serum dickkopf-1 (DKK1) level in menopausal women with rheumatoid arthritis (RA) secondary to osteoporosis (OP). Methods　A total of 236 menopausal female patients diagnosed in the Second Affiliated Hospital of Nanchang University from May 2019 to...

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Bibliographic Details
Published inJie fang jun yi xue za zhi Vol. 46; no. 4; p. 361
Main Authors Zi-Huan PEI, Jia-Yi, HUANG, Yu-Han, LIU, Ting-Ting, HU, Xiao-Hang, LI, Xu, LI, Ting-Ting ZENG, Yong-Jian, TIAN, Jian-Lin, YU, WU, Yang, Li-Ming1 TAN
Format Journal Article
LanguageChinese
Published Beijing People's Military Medical Press 01.01.2021
Subjects
Fractures
Osteoporosis
Rheumatoid arthritis
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Summary:Objective　To explore the clinical diagnostic value of serum dickkopf-1 (DKK1) level in menopausal women with rheumatoid arthritis (RA) secondary to osteoporosis (OP). Methods　A total of 236 menopausal female patients diagnosed in the Second Affiliated Hospital of Nanchang University from May 2019 to September 2020 were collected, including 44 patients with OP secondary to RA set as RA+OP group, 150 patients with RA without OP set as RA group, and 42 patients with OP set as OP group, respectively. At the same time, 43 healthy menopausal women in our hospital at the same period were selected as control group. Serum DKK1 was detected by ELISA. The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were detected by capillary method and rate-scattering turbidimetry, respectively; The bone metabolism indexes such as parathyroid hormone (PTH), type Ⅰ procollagen C-terminal propeptide (CTX), 25-hydroxy vitamin D3 [25-(OH)D3], type Ⅰ procollagen N-terminal propeptide (PINP) and osteocalcin were detected
ISSN:0577-7402
DOI:10.11855/j.issn.0577-7402.2021.04.07