Inflammatory cytokine patterns associated with neurological diseases in COVID‐19

Patients with COVID‐19 can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of IL‐2, IL‐4, IL‐6, IL‐10, IL‐12, CXCL8, and CXCL10 in the cerebrospinal fluid (CSF). Conversely, encephalopathy was associate...

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Published inAnnals of Neurology
Main Authors Espíndola, Otávio M, Gomes, Yago C P, Brandão, Carlos Otávio, Torres, Rafael C, Siqueira, Marilda, Soares, Cristiane N, Marco Antonio S D Lima, Ana Claudia C B Leite, Venturotti, Carolina O, Carvalho, Ana Julia C, Torezani, Guilherme, Araujo, Abelardo Q C, Marcus Tulius T Silva
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LanguageEnglish
Published Hoboken John Wiley & Sons, Inc 06.02.2021
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Abstract Patients with COVID‐19 can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of IL‐2, IL‐4, IL‐6, IL‐10, IL‐12, CXCL8, and CXCL10 in the cerebrospinal fluid (CSF). Conversely, encephalopathy was associated with high serum levels of IL‐6, CXCL8, and active TGF‐β1. Inflammatory syndromes of the central nervous system (CNS) in COVID‐19 can appear early, as a para‐infectious process without significant systemic involvement, or without direct evidence of SARS‐CoV‐2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines.
AbstractList Patients with COVID‐19 can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of IL‐2, IL‐4, IL‐6, IL‐10, IL‐12, CXCL8, and CXCL10 in the cerebrospinal fluid (CSF). Conversely, encephalopathy was associated with high serum levels of IL‐6, CXCL8, and active TGF‐β1. Inflammatory syndromes of the central nervous system (CNS) in COVID‐19 can appear early, as a para‐infectious process without significant systemic involvement, or without direct evidence of SARS‐CoV‐2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines.
Author Siqueira, Marilda
Marco Antonio S D Lima
Espíndola, Otávio M
Soares, Cristiane N
Araujo, Abelardo Q C
Gomes, Yago C P
Brandão, Carlos Otávio
Ana Claudia C B Leite
Marcus Tulius T Silva
Venturotti, Carolina O
Carvalho, Ana Julia C
Torezani, Guilherme
Torres, Rafael C
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