Inflammatory cytokine patterns associated with neurological diseases in COVID‐19

Patients with COVID‐19 can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of IL‐2, IL‐4, IL‐6, IL‐10, IL‐12, CXCL8, and CXCL10 in the cerebrospinal fluid (CSF). Conversely, encephalopathy was associate...

Full description

Saved in:
Bibliographic Details
Published inAnnals of Neurology
Main Authors Espíndola, Otávio M, Gomes, Yago C P, Brandão, Carlos Otávio, Torres, Rafael C, Siqueira, Marilda, Soares, Cristiane N, Marco Antonio S D Lima, Ana Claudia C B Leite, Venturotti, Carolina O, Carvalho, Ana Julia C, Torezani, Guilherme, Araujo, Abelardo Q C, Marcus Tulius T Silva
Format Web Resource
LanguageEnglish
Published Hoboken John Wiley & Sons, Inc 06.02.2021
Online AccessGet full text

Cover

More Information
Summary:Patients with COVID‐19 can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of IL‐2, IL‐4, IL‐6, IL‐10, IL‐12, CXCL8, and CXCL10 in the cerebrospinal fluid (CSF). Conversely, encephalopathy was associated with high serum levels of IL‐6, CXCL8, and active TGF‐β1. Inflammatory syndromes of the central nervous system (CNS) in COVID‐19 can appear early, as a para‐infectious process without significant systemic involvement, or without direct evidence of SARS‐CoV‐2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines.
DOI:10.1002/ana.26041