HYPOTHYROIDISM-A RISK FACTOR FOR THE NON-ALCOHOLIC FATTY LIVER DISEASE

Subclinical hypothyroidism, which refers to an elevated thyroid-stimulating hormone (TSH) level and a normal free thyroxine (T4) level, has been associated with metabolic syndrome, cardiovascular diseases and mortality10. Because the thyroid hormones play a fundamental role in lipid metabolism, hypo...

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Published inResearch and science today no. 2; pp. 139 - 146
Main Authors Popescu, Mihaela, Popescu, Iulian Alin, Neagoe, Daniela, Ghenea, Alice, Iana, Oana, Bäleanu, Vlad Dumitru, Ungureanu, Anca, Ungureanu, Georgiana
Format Journal Article
LanguageEnglish
Published Targu-Jiu University Constantin Brancusi of Târgu-Jiu 01.10.2020
Subjects
Abdomen
Adipose tissue
Age
Alcoholism
Blood pressure
Body fat
Body mass index
Cardiovascular diseases
Cirrhosis
Disease
Enzymes
Etiology
Fatty liver
Fibrosis
Glucose
Hepatitis
Hormones
Hypercholesterolemia
Hyperlipidemia
Hypertension
Hypothyroidism
Insulin
Insulin resistance
Lipid metabolism
Lipid peroxidation
Lipids
Lipolysis
Liver
Liver cirrhosis
Liver diseases
Metabolic disorders
Metabolic syndrome
Obesity
Pathogenesis
Patients
Peroxidation
Risk analysis
Risk factors
Steatosis
Thyroid
Thyroid gland
Thyroid hormones
Thyroid-stimulating hormone
Thyroxine
Triglycerides
Womens health
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Summary:Subclinical hypothyroidism, which refers to an elevated thyroid-stimulating hormone (TSH) level and a normal free thyroxine (T4) level, has been associated with metabolic syndrome, cardiovascular diseases and mortality10. Because the thyroid hormones play a fundamental role in lipid metabolism, hypothyroidism may cause hypercholesterolemia and play an essential role in the pathogenesis of Non-alcoholic fatty liver disease (NAFLD)11. NAFLD has been recognized as the most common liver disease and includes a spectrum of hepatic dysfunctions ranging from simple steatosis to non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma12. Because the mechanism underlying the development of NAFLD has been linked to insulin resistance and metabolic syndrome, NAFLD is considered to be the hepatic manifestation of metabolic syndrome13 and the associations with many predictors of cardiovascular disease have been reported14. While the exact etiology of NAFLD and NASH is unclear, insulin resistance appears to be central to the pathogenesis of NASH by allowing inappropriate levels of lipolysis from the adipose tissue and impairing peripheral glucose disposal. Besides insulin resistance, NAFLD is also closely associated with other characteristics of the metabolic syndrome including central obesity, hypertension and hyperlipidemia. [...]an irregular lipid peroxidation leads to direct damage to the liver, with inflammation and even fibrosis.
ISSN:2247-4455
2285-9632