High fidelity blood flow in a patient-specific arteriovenous fistula

An arteriovenous fistula, created by artificially connecting segments of a patient's vasculature, is the preferred way to gain access to the bloodstream for kidney dialysis. The increasing power and availability of supercomputing infrastructure means that it is becoming more realistic to use si...

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Bibliographic Details
Published inarXiv.org
Main Authors McCullough, J W S, Coveney, P V
Format Paper
LanguageEnglish
Published Ithaca Cornell University Library, arXiv.org 11.06.2021
Subjects
Arteries
Blood flow
Clinical medicine
Computational fluid dynamics
Fistula
Forearm
Physiology
Three dimensional models
Virtual humans
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Summary:An arteriovenous fistula, created by artificially connecting segments of a patient's vasculature, is the preferred way to gain access to the bloodstream for kidney dialysis. The increasing power and availability of supercomputing infrastructure means that it is becoming more realistic to use simulations to help identify the best type and location of a fistula for a specific patient. We describe a 3D fistula model that uses the lattice Boltzmann method to simultaneously resolve blood flow in patient-specific arteries and veins. The simulations conducted here, comprising vasculatures of the whole forearm, demonstrate qualified validation against clinical data. Ongoing research to further encompass complex biophysics on realistic time scales will permit the use of human-scale physiological models for basic and clinical medicine.
ISSN:2331-8422