A simple and efficient route to 2‐arylimidazopyridines and zolimidine using automated grindstone chemistry

A green and efficient mechanochemical method for the synthesis of a series of 2‐arylimidazo[1,2‐a]pyridines was developed using an electrical grinder. I2 catalyzed mechanochemical grinding facilitates the cyclocondensation reaction between various aryl methyl ketones and 2‐aminopyridines to afford 2...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 57; no. 11; pp. 4099 - 4107
Main Authors Das, Dharmendra, Bhutia, Zigmee T, Panjikar, Padmini C, Chatterjee, Amrita, Banerjee, Mainak
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc 01.11.2020
Subjects
Ambient temperature
Aromatic compounds
Ketones
Pyridines
Reaction time
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Summary:A green and efficient mechanochemical method for the synthesis of a series of 2‐arylimidazo[1,2‐a]pyridines was developed using an electrical grinder. I2 catalyzed mechanochemical grinding facilitates the cyclocondensation reaction between various aryl methyl ketones and 2‐aminopyridines to afford 2‐arylimidazo[1,2‐a]pyridines in good yields at ambient temperature. The method was successfully used for the gram‐scale synthesis of a marketed drug, zolimidine. The noticeable advantages of this environmentally sustainable protocol include mild conditions, simple instrumentation, inexpensive catalyst, atom economy, short reaction time etc.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4106